At some point in our business lives, we all make mistakes – from minor ones to devastatingly major errors of judgment. Most successful businesses survive even the worst of them. We learn and move on.

But not these three CEOs. They soldiered forward – not listening to their advisors, Boards or employees – wiping out immense amounts of their company’s value. One Founder/CEO, Elizabeth Holmes, even managed to destroy the company she had so passionately started.

Watch the video above for a short but compelling interview clip about some very big mistakes that you should avoid.